TOBRAMYCIN LEVEL TROUGH

Code
900.5310
Name
TOBRAMYCIN LEVEL TROUGH
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Aminoglycosides; Nebcin
CPT Codes
80200
Site
SBMF
Reference Test
ATLAS Test Code

Specimen Information

Type

Red, Serum

Volume

1.0 ml.  Allow serum specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to a plastic transport tube

Transport Info

Refrigerated
3 day stability,

Frozen
1 month stability

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Turbidimetric

Clinical Significance

Used in the diagnosis and treatment of tobramycin overdose and in monitoring levels of tobramycin to ensure appropriate therapy.

Tobramycin is an aminoglycoside antibiotic used in the treatment of infections caused by Pseudomonas aeruginosa, Proteus species, E. coli, Klebsiella, Serratia, Citrobacter, Staphylococcus aureus, Enterobacter and other bacilli. Tobramycin's toxic effect is produced by interfering with ribosomal protein synthesis. Tobramycin undergoes very little, if any, metabolization and is, therefore, eliminates the parent drug by glomerular filtration. The half-life of tobramycin in serum or plasma correlates closely with renal function and thus is quite variable between individuals and within one individual over times. Serum or plasma tobramycin concentration is also impacted by mode of administration, the volume of extracellular fluid, the duration of the treatment and physiological changes during the illness and therapy.The therapeutic range of tobramycin should be measured at peak as well as trough concentrations. In patients with pre-existing renal damage or those to whom tobramycin has been administered for prolonged periods or in doses above the therapeutic range, hearing impairment and/or nephrotoxicity may develop. Therefore, monitoring of peak and trough tobramycin serum or plasma levels is critical in the prevention of these serious complications with the adjustment of dosage administration as indicated.

Back