TOPIRAMATE

Code
900.5260
Name
TOPIRAMATE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Topamax
CPT Codes
80201
Site
SBMF
Reference Test
23125
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

0.5 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Frozen

Fasting Required?
False
Patient Instructions

Reference Range

Peak: 9-12 mg/mL
Trough: 2-4 mg/mL

Methodology

Fluorescence Polarization

Clinical Significance

Monitor topiramate therapy to ensure the patient is receiving a dose adequate to achieve anti-epileptic activity while avoiding side effects associated with high blood levels.

Topiramate, an anticonvulsant drug used in the treatment of epilepsy, is a sulfamate-substituted monosaccharide, structurally dissimilar to other standard anticonvulsant drugs. Topiramate is routinely administered orally, absorbed rapidly and metabolized minimally. Peak plasma concentrations are reached 2-3 hours after dosing. Binding to plasma proteins is low, normally less than 15%. Elimination is predominantly renal as unaltered Topiramate, with an elimination half-life of 20-30 hours.

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