TOTAL PROTEIN,24 HR URINE

Code
500.1200
Name
TOTAL PROTEIN,24 HR URINE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
CPT Codes
84156, 81050
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Urine, 24-Hour

Volume

Transport Info

Room Temperature
1 day stability

Refrigerated
7 day stability

Frozen
1 month stability

Fasting Required?
False
Patient Instructions

No preservative

Reference Range

0-150 mg/24hr

Methodology

Colorimetric

Clinical Significance

Used in the diagnosis and treatment of disease conditions such as renal or heart disease, or thyroid disorders, which are characterized by proteinuria or albuminuria.

Normal urine protein consists of albumin (=35 mg/24 hours), other plasma proteins (ie, globulins, haptoglobin, beta2 microglobulin, and light chain). Tamm-Horsfall glycoprotein secreted by renal tubular cells may correlate =50 mg/ 24 hours. Urinary protein in normals tends to increase with age, exercise, and recumbent position. Nephrotic syndromes are the causes of the most severe urinary protein losses. Nephrotic syndrome is usually defined by degree of proteinuria (ie, proteinuria >50 mg/kg/day). After time, additional signs and symptoms occur, including hypoproteinemia, hypoalbuminemia, elevation of alpha2 globulin with decreased gamma globulin on electrophoresis, hyperlipidemia and edema. Twenty-four hour collections are preferable for the evaluation of nephrotic states and inflammatory renal disorders. Creatinine, creatinine clearance, BUN, serum protein electrophoresis, ANA, anti-DNA antibodies, and complement levels (including total complement, C3, C4) are among useful tests to work up patients with proteinuria. Urine electrophoresis, immunofixation, and immunoelectrophoresis are useful in patients older than 35 years of age to investigate possible diagnosis of amyloidosis, myeloma, and Waldenström’s macroglobulinemia.

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