VANCOMYCIN RANDOM

Code
600.5500
Name
VANCOMYCIN RANDOM
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
Aminoglycosides; Vancocin
CPT Codes
80202
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
48 day stability

Frozen
4 week stability

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Turbidimetric

Clinical Significance

Used in monitoring therapeutic vancomycin level in blood.

Vancomycin is a glycopeptide antibiotic that is bactericidal against many gram-positive and some gram-negative cocci. It is useful in therapy of severe staphylococcal (including methicillin-resistant staphylococci) infections in patients who cannot receive or who have failed to respond to the penicillins and cephalosporins. Vancomycin HCl has been used successfully alone in the treatment of staphylococcal (including methicillin-resistant staphylococci) endocarditis. Because of its toxicity, vancomycin should be used with care in patients with renal insufficiency. Concurrent and sequential use of other neurotoxic and/or nephrotoxic antibiotics, particularly streptomycin, neomycin, kanamycin, gentamicin, cephaloridine, paramomyfin, viomycin, polymysin B, colistin, tobramycin and amikacin, requires careful monitoring of vancomycin.Strong correlations have been shown between serum levels and both therapeutic effect and toxicity in specific patient types. Peak serum levels of vancomycin in the range of 30 to 40 µg/mL and trough blood levels of 5 to 10 µg/mL are suggested for optimal therapeutic effectiveness. In the presence of impaired renal function, unnecessarily high blood levels of vancomycin (approximately 90 µg/mL) may damage the eighth cranial nerve and cause deafness.

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