VITAMIN B12

Code
600.6202
Name
VITAMIN B12
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
VIT ; B12
CPT Codes
82607
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST
Na Hep

Volume

1.0 ml

Transport Info

Refrigerated
24 hour stability

Frozen (Freeze Only once)
2 month stability

Protect from Light

Fasting Required?
True
Patient Instructions

Reference Range

Normal=200-900 pg/mL

Methodology

Chemiluminescence

Clinical Significance

Diagnose the etiology of anemia.

Nutritional and macrocytic anemias can be caused by a deficiency of vitamin B12. This deficiency can result from diets devoid of meat and bacterial products, from alcoholism, or from structural/functional damage to digestive or absorptive processes (forms of pernicious anemia). Malabsoportion is the major cause of this deficiency through pancreatic deficiency, gastric atrophy or gastrectomy, intestinal damage, loss of intestinal vitamin B12 binding protein (intrinsic factor), production of autoantibodies directed against intrinsic factor or related causes. This vitamin is necessary for normal metabolism, DNA synthesis and red blood cell regeneration. Untreated deficiencies will lead to megaloblastic anemia and vitamin B12 deficiency results in irreversible central nervous system degeneration. Since a deficiency of either vitamin B12 or folate can cause megaloblastic anemia, it is advisable to determine the concentration of both vitamin B12 and folate in order to properly diagnose the etiology of anemia.

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