VITAMIN E

Code
900.5581
Name
VITAMIN E
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Tocopherol
CPT Codes
84446
Site
SBMF
Reference Test
23303
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate light protected or foil wrapped plastic tube
Refrigerated

Fasting Required?
True
Patient Instructions

Fasting for at least 8 hours
Recommend abstaining from alcohol for 24 hours before specimen collection

Reference Range

0–1 month 1.0–3.5 mg/L
2–5 months 2.0–6.0 mg/L
6 months–1 year 3.5–8.0 mg/L
2–12 years 5.5–9.0 mg/L
13 years and older 5.5–18.0 mg/L

Methodology

High Performance Liquid Chromatography (HPLC)

Clinical Significance

Quantitation of circulating Vitamin E (tocopherol) concentration
Vitamin E is an antioxidant that is widely distributed in foodstuffs, such as wheat germ oil and sunflower oil, grains and nuts. It is absorbed in the small intestine in the presence of bile. Although deficiency rarely occurred from diet, mal-absorption and deficiency may develop in cases of chronic intraluminal interstinal bile deficiency.

Inhibition of free-radical chain reactions of lipid peroxidation is the most thoroughly defined role of vitamin E. Vitamin E inhibits lipid peroxidation mainly because it scavenges lipid peroxyl radicals faster than the radical can react with adjacent fatty acid side chains or membrane proteins. The resultant tocopheryl or tocotrienyl radicals may then react with further peroxyl radicals to produce tocopherones (nonradicals), or be generated by transferring an electron to ascorbate to form the ascorbyl radical. Vitamins E and C act synergistically to reduce lipid peroxidation.

Vitamin E has been also recognized as necessary for neurological and reproductive functions, for protecting the red cell from hemolysis and for prevention of retinopathy in premature infants.

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