- VITAMIN E
- Start Date
- Expiration Date
- CPT Codes
- Reference Test
- Transport Info
Centrifuge and immediately transfer serum to separate light protected or foil wrapped plastic tube
- Fasting Required?
- Patient Instructions
Fasting for at least 8 hours
Recommend abstaining from alcohol for 24 hours before specimen collection
- Reference Range
0–1 month 1.0–3.5 mg/L
2–5 months 2.0–6.0 mg/L
6 months–1 year 3.5–8.0 mg/L
2–12 years 5.5–9.0 mg/L
13 years and older 5.5–18.0 mg/L
High Performance Liquid Chromatography (HPLC)
Quantitation of circulating Vitamin E (tocopherol) concentration
Vitamin E is an antioxidant that is widely distributed in foodstuffs, such as wheat germ oil and sunflower oil, grains and nuts. It is absorbed in the small intestine in the presence of bile. Although deficiency rarely occurred from diet, mal-absorption and deficiency may develop in cases of chronic intraluminal interstinal bile deficiency.
Inhibition of free-radical chain reactions of lipid peroxidation is the most thoroughly defined role of vitamin E. Vitamin E inhibits lipid peroxidation mainly because it scavenges lipid peroxyl radicals faster than the radical can react with adjacent fatty acid side chains or membrane proteins. The resultant tocopheryl or tocotrienyl radicals may then react with further peroxyl radicals to produce tocopherones (nonradicals), or be generated by transferring an electron to ascorbate to form the ascorbyl radical. Vitamins E and C act synergistically to reduce lipid peroxidation.
Vitamin E has been also recognized as necessary for neurological and reproductive functions, for protecting the red cell from hemolysis and for prevention of retinopathy in premature infants.