West Nile Virus IgG Antibody, Serum

Code
900.5612
Name
West Nile Virus IgG Antibody, Serum
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
WNV IgG
CPT Codes
86789
Site
SBMF
Reference Test
45757
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0mL

Transport Info

Centrifuge and transfer serum to separate plastic tube within 2 hours of collection.  Refrigerated.

Fasting Required?
False
Patient Instructions

Mark specimen as "acute" or "convalescent"

Reference Range

1.29 IV or less: Negative ‑ No significant level of West Nile virus IgG antibody detected.
1.30‑1.49 IV: Equivocal ‑ Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10‑14 days may be helpful.
1.50 IV or greater: Positive ‑ Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection.

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

This test is intended to be used as a semi‑quantitative means of detecting West Nile virus‑specific IgG in serum specimens in which there is a clinical suspicion of West Nile virus infection. This test should not be used solely for quantitative purpose, nor should the results be used without correlation to clinical history or other data. Because other members of the Flaviviridae family, such as St. Louis encephalitis virus, show extensive cross‑reactivity with West Nile virus, serologic testing specific for these species should be considered.

Seroconversion between acute and convalescent sera is considered strong evidence of current or recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.

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