ZINC PROTOPORPHYRIN

Code
900.5675
Name
ZINC PROTOPORPHYRIN
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
ZPP
CPT Codes
84202
Site
SBMF
Reference Test
23245
ATLAS Test Code

Specimen Information

Type

SPECIAL INSTRUCTIONS, CALL LAB

Volume

Transport Info

Fasting Required?
False
Patient Instructions

Reference Range

0-70 ╬╝molZP/mol heme

Methodology

Front Surface Fluorometry

Clinical Significance

Monitoring iron metabolism.

The porphyrias are a group of genetic abnormalities of heme synthesis in which abnormal concentrations of heme precursors accumulate. Many conditions that interfere with iron metabolism in the developing erythrocyte will induce an increase in ZPP and porphyrins. Such conditions include chronic inflammatory processes, iron deficiency, and lead exposure. Depending upon clinical circumstances, other tests, such as whole blood lead or serum ferritin, may be necessary for evaluation. Serum porphyrins are more specific for inherited porphyrin disorders, such as erythropoietic protoporphyria.Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

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