ZINC PROTOPORPHYRIN
- Code
- 900.5675
- Name
- ZINC PROTOPORPHYRIN
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- ZPP
- CPT Codes
- 84202
- Site
- SBMF
- Reference Test
- 23245
Specimen Information
- Type
SPECIAL INSTRUCTIONS, CALL LAB
- Volume
- Transport Info
- Fasting Required?
- False
- Patient Instructions
- Reference Range
0-70 μmolZP/mol heme
- Methodology
Front Surface Fluorometry
Clinical Significance
Monitoring iron metabolism.
The porphyrias are a group of genetic abnormalities of heme synthesis in which abnormal concentrations of heme precursors accumulate. Many conditions that interfere with iron metabolism in the developing erythrocyte will induce an increase in ZPP and porphyrins. Such conditions include chronic inflammatory processes, iron deficiency, and lead exposure. Depending upon clinical circumstances, other tests, such as whole blood lead or serum ferritin, may be necessary for evaluation. Serum porphyrins are more specific for inherited porphyrin disorders, such as erythropoietic protoporphyria.Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.