HEPATITIS DELTA VIRUS ANTIGEN

Code
000.0000
Name
HEPATITIS DELTA VIRUS ANTIGEN
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
HDV Ag
CPT Codes
87380
Site
SBMF
Reference Test
45194
ATLAS Test Code

Specimen Information

Type

Red,Plain

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Frozen

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Fasting Required?
False
Patient Instructions

Reference Range

Negative

Methodology

Qualitative Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

The Hepatitis Delta Virus (HDV) is a defective RNA virus, composed of a core presenting the delta-specific antigen and encapsulated by Hepatitis B surface antigen, which requires the helper function of Hepatitis B virus (HBV) to support its replication.

Infection by HDV occurs in the presence of acute or chronic HBV infection. When acute delta and acute HBV simultaneously occur, the illness becomes severe and clinical and biochemical features may be indistinguishable from those of HBV infection alone. In contrast, a patient with chronic HBV infection can support HDV replication indefinitely, usually with a less severe illness appearing as a clinical exacerbation.

The determination of HDV specific serological markers represents, in these cases, an important tool to the clinician for the classification of the etiological agent, and follow up of infected patients and monitoring their treatment. The detection of HDV IgM and IgG antibodies allows the classification of the illness and the monitoring of the seroconversion event. The Hepatitis D antigen test is intended for the follow-up of HDV infected individuals.

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