HEPARIN-ASSOCIATED ANTIBODY, PF4
- HEPARIN-ASSOCIATED ANTIBODY, PF4
- Start Date
- Expiration Date
- HIT; Heparin Induced Thrombocytopenia; PF4
- CPT Codes
- Reference Test
- ATLAS Test Code
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
- Fasting Required?
- Patient Instructions
- Reference Range
Anti-HEPARIN-PF4: Less than 0.40 O.D.
Enzyme-Linked Immunosorbent Assay (ELISA)
Heparin is one of the most common causes of drug-induced thrombocytopenia. Heparin-induced thrombocytopenia (HIT) is subdivided into two groups. Type I is attributed to a direct interaction between heparin and platelets. Type I HIT is generally considered a benign condition and is not antibody-mediated. Type II HIT is of immunological origin and characterized by immune-mediated activation and clearance of platelets. It occurs 5-14 days after heparin exposure in 1-3% of patients and is associated with thrombosis. In untreated HIT, progression to thrombosis occurs in up to 50% of patients. Venous thromboembolism accounts for the majority of the thrombotic events but arterial thrombosis may also occur.