ENDOMYSIAL IGA ANTIBODY, IFA

Code
900.1430
Name
ENDOMYSIAL IGA ANTIBODY, IFA
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
EMA IFA; Endomysial IgA Ab
CPT Codes
86256
Site
SBMF
Reference Test
28221
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Methodology

Indirect Fluorescent Antibody (IFA)

Clinical Significance

Approximately 70% of patients with dermatitis herpetiformis and almost 100% of patients with active celiac disease will demonstrate endomysial IgA antibodies.
Celiac disease and dermatitis herpetiformis are two recognized forms of gluten sensitive enteropathy (GSE). A gluten-free diet controls GSE and associated risks. IgA endomysial antibodies (EMA) is one of the recommended serological tests shown to be useful in diagnosing these conditions.
Selective IgA deficiency is increased tenfold in individuals with celiac disease, therefore, at least 3% of affected patients will test negative for this reason alone.

The endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase.

Back