GANGLIOSIDE IGG/IGM ANTIBODIES (ASIALO-GM1, GM1, GM2, GD1A, GD1B, & GQ1B)

Code
000.0000
Name
GANGLIOSIDE IGG/IGM ANTIBODIES (ASIALO-GM1, GM1, GM2, GD1A, GD1B, & GQ1B)
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
83516x6
Site
SBMF
Reference Test
44468
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barré syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80% of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Back