17-HYDROXYCORTICOSTEROIDS, 24UR

Code
900.0099
Name
17-HYDROXYCORTICOSTEROIDS, 24UR
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
17-OHCS; Hydroxycorticosteroids (Quantitative Urine)
CPT Codes
83491
Site
SBMF
Reference Test
44453
ATLAS Test Code

Specimen Information

Type

Urine, 24 Hour

Volume

12.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

17-Hydroxycorticosteroids per gram of creatinine: 2.0-6.5 mg/g creatinine
17-Hydroxycorticosteroids: 4.0-14.0 mg/day

Methodology

Porter-Silber

Clinical Significance

Evaluation of glucocorticoid production and neuroendocrine function.

Evaluation of androgenic adrenal and testicular function in normal males.

Primarily adrenal androgenic secretion in normal females.

Cortisol is a steroid hormone released from the adrenal cortex in response to adrenocorticotrophic hormone (ACTH). Cortisol is then metabolized by the liver and other tissues to inactive products such as 17-hydroxycorticosteroids (17-OHCS), which are excreted by the body in the urine. Measurements of 17-OHCS in the urine can be helpful in determining if the body is producing too much cortisol. Elevated levels of 17-OHCS may indicate: • Cushing’s syndrome caused by adrenal tumor • Cushing’s syndrome caused by pituitary tumor • Ectopic ACTH-producing tumor • Severe physical or emotional stress Elevated levels of 17-OHCS may also exist with: • Obesity • Pregnancy • Severe hypertension • Hydrocortisone therapy Lower than normal levels of 17-OHCS may indicate: • Adrenal hemorrhage • Adrenal insufficiency (suppressed from steroid therapy) • Addison’s disease • Adrenal infarction • Hereditary enzyme deficiency • Hypopituitarism • Surgical removal of the adrenal gland

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