- 17-HYDROXYCORTICOSTEROIDS, 24UR
- Start Date
- Expiration Date
- 17-OHCS; Hydroxycorticosteroids (Quantitative Urine)
- CPT Codes
- Reference Test
Urine, 24 Hour
- Transport Info
- Fasting Required?
- Patient Instructions
- Reference Range
17-Hydroxycorticosteroids per gram of creatinine: 2.0-6.5 mg/g creatinine
17-Hydroxycorticosteroids: 4.0-14.0 mg/day
Evaluation of glucocorticoid production and neuroendocrine function.
Evaluation of androgenic adrenal and testicular function in normal males.
Primarily adrenal androgenic secretion in normal females.
Cortisol is a steroid hormone released from the adrenal cortex in response to adrenocorticotrophic hormone (ACTH). Cortisol is then metabolized by the liver and other tissues to inactive products such as 17-hydroxycorticosteroids (17-OHCS), which are excreted by the body in the urine. Measurements of 17-OHCS in the urine can be helpful in determining if the body is producing too much cortisol. Elevated levels of 17-OHCS may indicate: • Cushing’s syndrome caused by adrenal tumor • Cushing’s syndrome caused by pituitary tumor • Ectopic ACTH-producing tumor • Severe physical or emotional stress Elevated levels of 17-OHCS may also exist with: • Obesity • Pregnancy • Severe hypertension • Hydrocortisone therapy Lower than normal levels of 17-OHCS may indicate: • Adrenal hemorrhage • Adrenal insufficiency (suppressed from steroid therapy) • Addison’s disease • Adrenal infarction • Hereditary enzyme deficiency • Hypopituitarism • Surgical removal of the adrenal gland