QUINIDINE LEVEL

Code
600.4200
Name
QUINIDINE LEVEL
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
Cardioquin; Dura-Tabs; Extentabs; Quiniglute; Quinidex
CPT Codes
80194
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

2.0-5.0 ug/mL
Critical >5.0 ug/mL

Methodology

Fluorescence Polarization Immunoassay (FPIA)

Clinical Significance

Detect use. Evaluate therapeutic effect or possible toxicity.

Quinidine is used to correct heart rhythm disturbances and is an antiarrhythmic medication. Three actions are responsible for quinidine's ability to stop heart rhythm disturbances (arrhythmias) and prevent their recurrence. Quinidine decreases the speed of electrical conduction in the heart muscle. It prolongs the electrical phase during which heart muscle cells become electrically stimulated (action potential) and prolongs the recovery period during which the heart muscle cells cannot be stimulated (refractory period). Quinidine also blocks the normal effect of the vagus nerve on the heart, causing an increase in heart rate. Quinidine reduces the force of contraction of heart muscle cells, and therefore may further impair the pumping efficiency of a failing heart muscle. Quinidine blocks alpha-receptors in peripheral arteries which lowers blood pressure, and can cause excessively low blood pressure when combined with other blood vessel relaxing drugs (vasodilators).

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