BARBITURATES CONFIRMATION/QUANTITATION BY GC/MS, URINE
- BARBITURATES CONFIRMATION/QUANTITATION BY GC/MS, URINE
- Start Date
- Expiration Date
- Amytal; Fiorinal; Nembutal; Seconal; Luminal
- CPT Codes
- Reference Test
- ATLAS Test Code
- Transport Info
Room Temperature. Refrigerated acceptable.
- Fasting Required?
- Patient Instructions
- Reference Range
Negative (less than assay limit of detection)
Positive cutoff: 50 ng/mL
Quantitative Gas Chromatography-Mass Spectrometry (GC/MS)
Confirm positive screen results by an alternate, specific method; detect use. Barbiturates belong to a broad classification of CNS-depressant drugs known as sedative/hypnotics. Members of the barbiturate family have current medical uses and are prescribed as anticonvulsants, anesthetics, sedatives, and after severe head injury. Barbiturates are lipid soluble and rapidly absorbed into the bloodstream, readily penetrating the blood-brain barrier. Half lives range from 20 to 120 hours. Barbiturates are variously metabolized by the liver, some being excreted in the urine mainly as active and inactive metabolites and others mainly as unchanged drug. Depending on the specific barbiturate taken, urine may test positive for approximately 30 hours after administration or as long as several weeks. Positive result indicates exposure to drug and does not necessarily indicate impairment.