BARBITURATES CONFIRMATION/QUANTITATION BY GC/MS, URINE

Code
000.0000
Name
BARBITURATES CONFIRMATION/QUANTITATION BY GC/MS, URINE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Amytal; Fiorinal; Nembutal; Seconal; Luminal
CPT Codes
82205
Site
SBMF
Reference Test
47141
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

4.0 ml

Transport Info

Room Temperature. Refrigerated acceptable.

Fasting Required?
False
Patient Instructions

Reference Range

Negative (less than assay limit of detection)

Positive cutoff: 50 ng/mL

Methodology

Quantitative Gas Chromatography-Mass Spectrometry (GC/MS)

Clinical Significance

Confirm positive screen results by an alternate, specific method; detect use. Barbiturates belong to a broad classification of CNS-depressant drugs known as sedative/hypnotics. Members of the barbiturate family have current medical uses and are prescribed as anticonvulsants, anesthetics, sedatives, and after severe head injury. Barbiturates are lipid soluble and rapidly absorbed into the bloodstream, readily penetrating the blood-brain barrier. Half lives range from 20 to 120 hours. Barbiturates are variously metabolized by the liver, some being excreted in the urine mainly as active and inactive metabolites and others mainly as unchanged drug. Depending on the specific barbiturate taken, urine may test positive for approximately 30 hours after administration or as long as several weeks. Positive result indicates exposure to drug and does not necessarily indicate impairment.

Back