B-CELL AND T-CELL COMPREHENSIVE CLONALITY ASSESSMENT
- Code
- 000.0000
- Name
- B-CELL AND T-CELL COMPREHENSIVE CLONALITY ASSESSMENT
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- B-Cell and T-Cell receptor gene rearrangement
- CPT Codes
- 83891; 83900; 83901x14; 83909x10; 83912-26
- Site
- SBMF
- Reference Test
- 36168
Specimen Information
- Type
Lavender top (EDTA) tube, WHOLE BLOOD or BONE MARROW
Tissue: Formalin-fixed paraffin embedded tissue block, OR Tissue fixed in 10% buffered formalin
- Volume
Whole blood: 5.0 mL
Bone marrow: 3.0 mL
Tissue: 50 mg- Transport Info
Special Instructions--Call Lab
- Fasting Required?
- False
- Patient Instructions
- Reference Range
No monoclonal B cell population was detected by PCR analysis
No monoclonal T cell population was detected by PCR analysis- Methodology
Polymerase Chain Reaction (PCR)
Clinical Significance
Most malignant lymphomas are readily identifiable by laboratory methods such as histology and immunohistochemistry and/or flow cytometry. There are some lymphoproliferative lesions, however, where the abnormal lymphocytes are difficult to identify by routine histology. The clonal lymphocytes may be few in number within the tissue, or possibly dispersed within a background of polyclonal “reactive” lymphocytes or other inflammatory cells. Existing immunochemical markers may not readily identify the lymphocytes as malignant cells, a phenomenon that can occur in some T cell neoplasms. In such cases, identification of a genetically abnormal, clonal T or B lymphocyte population can be key to establishing the correct histopathologic diagnosis.