OLIGOCLONAL BANDING, CEREBROSPINAL FLUID AND SERUM (ARUP)

Code
900.2802
Name
OLIGOCLONAL BANDING, CEREBROSPINAL FLUID AND SERUM (ARUP)
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
O-Bands
CPT Codes
83916
Site
SBMF
Reference Test
44619
ATLAS Test Code

Specimen Information

Type

CSF AND Gold, SST

Volume

CSF: 1.5 mL
Serum: 1.0 mL

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Oligoclonal Bands, CSF Negative
Oligoclonal Bands Number, CSF 0 - 1 Bands
Oligoclonal Bands Interpretation By report
This test reports only the number of oligoclonal bands. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

Methodology

Qualitative Isoelectric Focusing/Electrophoresis

Clinical Significance

Oligoclonal banding is used in the diagnosis of multiple sclerosis (MS) and other diseases of the central nervous system. Oligoclonal bands can also be found in the CSF of patients with cryptococcal meningitis, idiopathic polyneuritis, neurosyphilis, chronic rubella panencephalitis, and subacute sclerosing panencephalitis.

Oligoclonal bands are present in the CSF of approximately 90 percent of MS patients. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

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