OLIGOCLONAL BANDING, CEREBROSPINAL FLUID AND SERUM (ARUP)
- Code
- 900.2802
- Name
- OLIGOCLONAL BANDING, CEREBROSPINAL FLUID AND SERUM (ARUP)
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- O-Bands
- CPT Codes
- 83916
- Site
- SBMF
- Reference Test
- 44619
Specimen Information
- Type
CSF AND Gold, SST
- Volume
CSF: 1.5 mL
Serum: 1.0 mL- Transport Info
Refrigerated
- Fasting Required?
- False
- Patient Instructions
- Reference Range
Oligoclonal Bands, CSF Negative
Oligoclonal Bands Number, CSF 0 - 1 Bands
Oligoclonal Bands Interpretation By report
This test reports only the number of oligoclonal bands. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.- Methodology
Qualitative Isoelectric Focusing/Electrophoresis
Clinical Significance
Oligoclonal banding is used in the diagnosis of multiple sclerosis (MS) and other diseases of the central nervous system. Oligoclonal bands can also be found in the CSF of patients with cryptococcal meningitis, idiopathic polyneuritis, neurosyphilis, chronic rubella panencephalitis, and subacute sclerosing panencephalitis.
Oligoclonal bands are present in the CSF of approximately 90 percent of MS patients. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.