BILIRUBIN, AMNIOTIC FLUID

Code
000.0000
Name
BILIRUBIN, AMNIOTIC FLUID
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Amniotic Fluid Bilirubin; OD 450
CPT Codes
82143
Site
SBMF
Reference Test
44909
ATLAS Test Code

Specimen Information

Type

Amniotic fluid, Light-proof (amber) plastic container with screw-top cap

Volume

3.0 ml

Transport Info

Light-proof (amber) plastic container with screw-top cap
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Normal: 0.02 OD or less; depends on gestational age.

Methodology

Spectrophotometry

Clinical Significance

Predictor of the severity of hemolytic disease.

Spectrophotometric analysis of amniotic fluid in Rh-sensitized pregnancies shows an abnormal peak at 450 nm caused by bilirubin and several related bilirubinoid pigments. The magnitude of the increase in absorbance above the baseline value usually correlates well, for any gestational age, with the intensity of the hemolytic disease. The higher the DA450, in relation to the gestational age, the more severe the hemolytic disease. Generally, a decreasing amniotic fluid bilirubin trend indicates a fetus that will survive, and a horizontal or rising bilirubin indicates that there is severe erythroblastosis fetalis. Although a single amniotic fluid analysis from a 28-32 week gestation can be predictable of the severity of hemolytic disease, multiple sequential determinations are most often necessary.

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