BILIRUBIN,TOTAL

Code
400.3200
Name
BILIRUBIN,TOTAL
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
Total Bili; Tbili
CPT Codes
82247
Site
Main Lab
Reference Test
ATLAS Test Code

BIL

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Room Temperature 1 day stability Refrigerated 7 day stability Frozen 6 month stability

Fasting Required?
False
Patient Instructions

Protect from light

Reference Range

See Report

Methodology

Colorimetric

Clinical Significance

Liver and biliary tests are useful in the differential diagnosis of jaundice from bilirubin overproduction (hemolysis), decreased uptake (Gilbert's), decreased conjugation (heptatocellular disease, neonatal immaturity, Crigler-Najjar, drug inhibition), decreased excretion into bile (hepatocellular disease, familial, drug-induced, pregnancy, obstructive bile duct disease). In obstructive jaundice, there is an increase in the total bilirubin, but the increase is primarily in the bilirubin glucuronide. In hemolytic jaundice and in neonatal jaundice, there is an increase primarily in the indirect (the difference between total and direct) bilirubin. In newborns, the jaundice may be caused by Rh, ABO or other blood group incompatibilities, by hepatic immaturity or by hereditary defects in bilirubin conjugation. Both direct and indirect bilirubin are increased in hepatitis. The relative proportion of the direct fraction increases with progression of the disease until eventually the liver loses its ability to carry out the conjugation reaction.

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