BLADDER TUMOR ASSOCIATED ANTIGEN, URINE
- BLADDER TUMOR ASSOCIATED ANTIGEN, URINE
- Start Date
- Expiration Date
- BTA stat® Test
- CPT Codes
- Reference Test
- Transport Info
- Fasting Required?
- Patient Instructions
If urine is to be used for other test, first remove an aliquot of the specimen (minimum of 2.0 mL) for this test to avoid contamination.
- Reference Range
Positive: Bladder tumor associated antigen detected
Negative: Bladder tumor associated antigen not detected
Indicated for bladder cancer surveillance.
Bladder tumor associated antigen is a new antigen that was isolated from urine found positive by the original BTA test and histology. Studies identified bladder tumor associated antigen as human complement factor H-related protein (hCFHrp). hCFHrp is similar in composition, structure, and function to human complement factor H (hCFH), which is found in human plasma at concentrations of approximately 480 mg/mL. In contrast, hCFHrp was produced by several human bladder cancer cell lines, but not by normal epithelial cell lines. hCFHrp was also not detected in the urine of individuals with other diseases. It is believed that production of this antigen may confer a selective growth advantage by allowing cancer cells to evade the host immune system. Results of the BTA stat® Test should not be interpreted as absolute evidence for the presence or absence of bladder cancer. Any disease that would cause endogenous hCFH to leak into the bladder can cause a positive result, including renal stones, nephritis, renal cancer, urinary tract infections, cystitis, or recent trauma to the bladder or urinary tract. The BTA stat® Test should not be used as a screening test for individuals without biopsy-confirmed bladder cancer.