BLADDER TUMOR ASSOCIATED ANTIGEN, URINE

Code
000.0000
Name
BLADDER TUMOR ASSOCIATED ANTIGEN, URINE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
BTA stat® Test
CPT Codes
86294
Site
SBMF
Reference Test
44403
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

2.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

If urine is to be used for other test, first remove an aliquot of the specimen (minimum of 2.0 mL) for this test to avoid contamination.

Reference Range

Positive: Bladder tumor associated antigen detected
Negative: Bladder tumor associated antigen not detected

Methodology

Qualitative Immunoassay

Clinical Significance

Indicated for bladder cancer surveillance.

Bladder tumor associated antigen is a new antigen that was isolated from urine found positive by the original BTA test and histology. Studies identified bladder tumor associated antigen as human complement factor H-related protein (hCFHrp). hCFHrp is similar in composition, structure, and function to human complement factor H (hCFH), which is found in human plasma at concentrations of approximately 480 mg/mL. In contrast, hCFHrp was produced by several human bladder cancer cell lines, but not by normal epithelial cell lines. hCFHrp was also not detected in the urine of individuals with other diseases. It is believed that production of this antigen may confer a selective growth advantage by allowing cancer cells to evade the host immune system. Results of the BTA stat® Test should not be interpreted as absolute evidence for the presence or absence of bladder cancer. Any disease that would cause endogenous hCFH to leak into the bladder can cause a positive result, including renal stones, nephritis, renal cancer, urinary tract infections, cystitis, or recent trauma to the bladder or urinary tract. The BTA stat® Test should not be used as a screening test for individuals without biopsy-confirmed bladder cancer.

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