BRUCELLA ANTIBODY

Code
000.0000
Name
BRUCELLA ANTIBODY
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
86622
Site
SBMF
Reference Test
44605
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

< 1:20 Negative

Methodology

Bacterial Agglutination

Clinical Significance

Brucella species cause epizootic infections in a variety of animals, as well as septicemic febrile illness and localized infections of bone or various organs in humans. Brucellosis is associated with occupational or vocational exposure to animals. Sporadic episodes of food-associated brucellosis have occurred in recent years. Brucellosis in humans has a variable incubation time, an insidious or abrupt onset, and no pathognomonic systems or signs. The laboratory confirmation of brucellosis is often based on serological tests rather than isolation of the organism. If brucellosis is suspected, a fourfold rise in titer greather than or equal to 1:160 is considered diagnostic. A single serum titer of 1:160 or 1:320 is suggestive of brucellosis when accompanied by a compatible clinical course in a patient with a history of potential exposures. Cross-reactions may occur between Brucella and F. tularensis antigens and antisera; therefore, parallel tests should be run with these antigens. • Sera from normal patients may show positive agglutination with febrile antigens due to a previous immunization, past infection, or cross-reacting antibodies. These titers should be lower and constant. Active infection or recent immunization will show higher titers that rise over time. It is prudent to test serum specimens taken at three- to five-day intervals after the onset of disease. A progressive increase in titer is indicative of recent infection or immunization.

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