NEURONAL NUCLEAR IGG ANTIBODIES (HU & RI) BY IMMUNOBLOT
- Code
- 900.2806
- Name
- NEURONAL NUCLEAR IGG ANTIBODIES (HU & RI) BY IMMUNOBLOT
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- ANNA; Hu; Ri
- CPT Codes
- 83516
- Site
- SBMF
- Reference Test
- 44512
Specimen Information
- Type
Gold, SST
- Volume
1.0 ml
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
Frozen- Fasting Required?
- False
- Patient Instructions
- Reference Range
Negative
- Methodology
Qualitative Immunoblot
Clinical Significance
ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein. ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.