NEURONAL NUCLEAR IGG ANTIBODIES (HU & RI) BY IMMUNOBLOT

Code
900.2806
Name
NEURONAL NUCLEAR IGG ANTIBODIES (HU & RI) BY IMMUNOBLOT
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
ANNA; Hu; Ri
CPT Codes
83516
Site
ARUP
Reference Test
47090
ATLAS Test Code

ANNA

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Refrigerate

Fasting Required?
False
Patient Instructions

Reference Range

Negative

Methodology

Qualitative Immunoblot

Clinical Significance

ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein. ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.

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