NEURONAL NUCLEAR IGG ANTIBODY BY IFA WITH REFLEX TO TITER & IMMUNOBLOT, SERUM

Code
000.0000
Name
NEURONAL NUCLEAR IGG ANTIBODY BY IFA WITH REFLEX TO TITER & IMMUNOBLOT, SERUM
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
ANNA; Hu; Ri
CPT Codes
86255, If reflexed add: 86256, 83516
Site
SBMF
Reference Test
44064
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Frozen

Fasting Required?
False
Patient Instructions

Reference Range

See report
ANNA antibodies are screened by IFA. If the IFA screen is 1:10, then a titer and immunoblot (Hu and Ri) will be added. Additional charges apply.

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)
Qualitative Immunoblot

Clinical Significance

ANNA-1 (anti-Hu) and ANNA-2 (anti-Ri) are screened by immunofluorescence and confirmed by immunoblot detection of antibody reactive with a 35-40 kDa (ANNA-1) or a 55 kDa (ANNA-2) neuronal protein. ANNA-1 is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable.

ANNA antibodies are screened by IFA. If the IFA screen shows reactivity at 1:10, the specimen will be titered to endpoint and confirmed (Hu or Ri) by immunoblot.

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