SOLUBLE TRANSFERRIN RECEPTOR
- SOLUBLE TRANSFERRIN RECEPTOR
- Start Date
- Expiration Date
- CPT Codes
- Reference Test
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
- Fasting Required?
- Patient Instructions
- Reference Range
Male - 18 years & older: 2.2-5.0 mg/L
Female - 18 years & older: 1.9-4.4 mg/L
Quantitative Immunoturbidimetric Assay
May be useful in combination with other tests of iron status in differentiating iron deficiency anemia from anemia of chronic disease.
The transferrin receptor (TfR) is expressed on the surface of human cells that require iron and acts as an iron transporting molecule. TfR binds plasma diferric transferrin and internalizes the Tfr-transferrin complex, where transferrin loses its iron to the cytosol. The receptor-bound transferrin recycles to the cell surface, loses the bound apotransferrin, and is able to bind another diferric transferrin. The expression of TfR depends on the concentration of Fe in the cellular cytoplasm. The concentration of soluble TfR (sTfR) has been reported to be proportional to the total amount of cell-associated TfR. The concentration of serum sTfR changes under two conditions: 1. Serum sTfR is increased in iron deficiency. 2. Serum sTfR is increased in conditions of high turnover (i.e., hemolytic anemia).