CA 15-3

Code
500.5225
Name
CA 15-3
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
Cancer Antigen 15-3; Cancer Antigen; Breast
CPT Codes
86300
Site
Main Lab
Reference Test
ATLAS Test Code

CA153

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated 5 day stability

Fasting Required?
False
Patient Instructions

Reference Range

*PERFORMED ON MONDAYS AND THURSDAYS ONLY* 0-31.3 U/mL

Methodology

Chemiluminescence

Clinical Significance

Useful in monitoring clinical course of breast cancer patients. CA-Breast (CA 15-3) measures a circulating adenocarcinoma-associated antigen belonging to a family of high molecular-weight glycoproteins normally present in human milk fat globule membranes. CA 15-3 is a sensitive marker that is useful in monitoring the clinical course of breast cancer patients. Whereas elevated levels are only present in a small percentage of patients with localized disease, two-thirds of cases with metastatic disease will have significantly elevated levels. It may also be elevated in patients with hepatitis, cirrhosis, sarcoidosis, tuberculosis, and systemic lupus erythematosus (SLE), as well as in other malignancies (e.g., pancreas, lung, ovary, colon, and liver). Assessments following therapy correlate well with disease progression. Because of relatively low sensitivity and a lack of specificity, CA 15-3 should not be used as a screening test.

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