CARDIOLIPIN IGA ANTIBODY

Code
900.0678
Name
CARDIOLIPIN IGA ANTIBODY
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
ACL IgA Antibody; Anticardiolipin IgA Antibody; Phospholipid IgA Antibody
CPT Codes
86147
Site
SBMF
Reference Test
28104
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

0.5 ml

Transport Info

Refrigerated 48 Hours
If specimen will not be received within 48 hours of collection, freeze serum and transport frozen

Fasting Required?
False
Patient Instructions

Reference Range

Less than 12 APL – Negative
12-20 APL – Intermediate
Greater than 20 APL – Positive

APL = IgA Phospholipid Units

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

To detect the presence of anti-cardiolipin antibodies (ACL) that have been shown to be associated with recurrent vascular thrombosis, recurrent spontaneous abortions, and thrombocytopenia—a combination that has been termed “Antiphospholipid Antibody Syndrome”.

Autoantibodies directed against certain phospholipids, including anti-cardiolipin antibodies (ACL), have been shown to be associated with recurrent vascular thrombosis, recurrent spontaneous abortions, and thrombocytopenia. This combination has been termed “Antiphospholipid Antibody Syndrome.”ACL antibodies are similar to other antiphospholipid antibodies called lupus anticoagulants (LA) because they can be seen in as many as 30% of patients with systemic lupus erythematosus. Despite its name and the associated prolongation of the PTT, there is a paradoxical increased association with recurrent thrombosis. ACL antibodies are also seen in patients with other autoimmune or connective tissue diseases, those undergoing chlorpromazine treatment, as well as patients with no known underlying diseases.Patients may demonstrate autoantibodies to either lupus anticoagulants or cardiolipin or both. The anticoagulant activity can be evaluated by the “Circulating Anticoagulant Detection Test.”The cardiolipin antibody test results are as either normal or low, moderate, and high positive for both IgG and IgM antibodies. Some authors have suggested that the criteria for diagnosis of “Antiphospholipid Antibody Syndrome” include both an abnormal clinical event (vascular thrombosis, immune thrombocytopenia, or recurrent abortion) as well as an abnormal laboratory test indicative of LA or a moderate or high titer of IgG ACL antibodies. Although there are individual patient exceptions, clinical symptoms are less common with ACL than with LA, particularly when the antiphospholipid syndromes are associated with infection or medication, are of low titer, and are of IgM isotype.

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