CARNITINE, FREE & TOTAL (INCLUDES CARNITINE, ESTERIFIED)

Code
000.0000
Name
CARNITINE, FREE & TOTAL (INCLUDES CARNITINE, ESTERIFIED)
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
L-carnitine Free & Total
CPT Codes
82379
Site
SBMF
Reference Test
44376
ATLAS Test Code

Specimen Information

Type

Green top (heparin) tube

Volume

0.5 ml

Transport Info

Centrifuge and mmediately transfer plasma to separate plastic tube
Frozen

CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered

Fasting Required?
False
Patient Instructions

Form required: "Patient History for Biochemical Genetic Testing"

Reference Range

See Report

Methodology

Tandem Mass Spectrometry (MS/MS)

Clinical Significance

Carnitine functions to transport long-chain fatty acids into mitochondria as a part of oxidative phosphorylation.

Carnitine functions to transport long-chain fatty acids into mitochondria as a part of oxidative phosphorylation. Synthesis by liver, kidney, and brain accounts for about 1/3 of daily needs with diet providing the rest. Associated lipid storage myopathies identified to date include: Carnitine deficiency (type I lipid storage myopathy). Carnitine-palmityltransferase (CPT) deficiency. Pyruvate-decarboxylase deficiency. Carnitine deficiency has been suggested as the primary cause of human lipid storage myopathy. Deficiencies have also been reported in premature infants and in patients with cirrhosis, renal failure, and long-term nutritional therapy (TPN). Serum carnitine levels increase during attacks of myoglobinuria.

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