CHLORIDE

Code
400.1600
Name
CHLORIDE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
CL
CPT Codes
82435
Site
Main Lab
Reference Test
ATLAS Test Code
CL

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Room Temperature
7 day stability

Refrigerated
7 day stability

Frozen
stable

Fasting Required?
False
Patient Instructions

Reference Range

95-110 mmol/L

Methodology

Ion-selective Electrode (ISE)

Clinical Significance

Used in the diagnosis and treatment of electrolyte and metabolic disorders; used in assessing kidney function.

Serum chloride is the major extracellular anion and counter-balances the major cation, sodium, maintaining electrical neutrality of the body fluids. Two thirds of the total anion concentration in extracellular fluids is chloride and it is significantly involved in maintaining proper hydration and osmotic pressure. Movement of chloride ions across the red blood cell membrane is essential for the transport of bicarbonate ions in response to changing concentrations of carbon dioxide. Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders such as cystic fibrosis and diabetic acidosis.• Increased Cl- levels may indicate: - Chronic hyperventilation - Cushing’s syndrome - Dehydration - Eclampsia - Excess infusion of normal saline - Kidney dysfunction - Metabolic acidosis - Renal tubular acidosis• Decreased Cl- levels may indicate: - Addison’s disease - Burns - Chronic respiratory acidosis (chronic hypoventilation) - Congestive heart failure - Excessive sweating - Gastric suction - Over hydration - Salt-losing nephritis - Syndrome of inappropriate ADH secretion - Vomiting.

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