ALPHA FETOPROTEIN TUMOR MARKER

Code
900.0175
Name
ALPHA FETOPROTEIN TUMOR MARKER
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
AFP Tumor Marker
CPT Codes
82105
Site
SBMF
Reference Test
30191
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Male and non-pregnant female: less than or equal to 6.1 ng/mL

Methodology

Chemiluminescenct Immunoassay (CLIA)

Clinical Significance

Quantitative measurements used to aid in the management of nonseminomatuous testicular cancer. Diagnosis of hepatocellular carcinoma, and certain germ cell neoplasms of the testis, ovary, retroperitoneum, and mediastinum; differential diagnosis of neonatal hepatitis versus biliary atresia in newborns. AFP is also increased in embryonal carcinoma and endodermal sinus tumor (extremely elevated amounts). High in some cases of massive hepatic necrosis, acute hepatitis, and chronic active hepatitis.

When used as a tumor marker, increased AFP levels have been observed in patients with primary hepatocellular carcinoma, nonseminomatous testicular carcinomas, and ovarian carcinomas, as well as in other epithelial tumors, especially those of the GI tract. AFP is also increased in some nonmalignant hepatic diseases, such as viral hepatitis and active cirrhosis. Levels of less than 200 ng/mL have been reported in these benign diseases. The specificity of AFP for malignancy is greatest at levels greater than 1,000 ng/mL. Smaller (more treatable) tumors will not be detected if this threshold is used, however. For this reason, levels between 15-200 ng/mL should be interpreted with caution.

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