D-DIMER

Code
200.2050
Name
D-DIMER
Category
None
Department
Coagulation
Start Date
Expiration Date
Synonyms
CPT Codes
85379
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Blue, Citrate

Volume

Tube must fill to top of label

Transport Info

Refrigerated
24 hour stability
If transport delayed, centrifuge blue top tube, transfer plasma to a separate plastic tube and Freeze.

Fasting Required?
False
Patient Instructions

Do not open tube unless freezing plasma.

Reference Range

0-0.62 ug/mL

Methodology

Photometric

Clinical Significance

D-Dimer assay aids in the diagnosis of thromboembolic events (deep vein thrombosis, pulmonary embolism and disseminated intravascular coagulation).

Coagulation activation results in the cleavage of fibrinogen to fibrin. The resulting fibrin molecules spontaneously aggregate and are cross-linked by Factor XIII; this produced a fibrin clot. The activation of the fibrinolytic system results in the conversion of plasminogen into the active protease plasmin that cleaves fibrinogen and fibrin into the fragments D and E. Due to the cross-linkages between the D-domains in the fibrin clot, the action of plasmin releases fibrin degradation products with cross-linked D-domains. The smallest unit is the D-dimer. Detection of cross-linked degradation products, of D-dimers, thus is indicative of reactive fibrinolysis.

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