DILUTE RUSSELL VIPER VENOM TIME (DRVVT)

Code
000.0000
Name
DILUTE RUSSELL VIPER VENOM TIME (DRVVT)
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
dRVVT
CPT Codes
85613
Site
SBMF
Reference Test
25050
ATLAS Test Code

Specimen Information

Type

Blue, Citrate

Volume

Transport Info

Separate plasma from cells immediately
• Promptly centrifuge 15 minutes
• Carefully transfer plasma portion of sample to separate plastic tube using plastic pipette
• Centrifuge transferred plasma sample again to produce platelet-poor plasma (PPP)
• Use second plastic pipette to carefully transfer PPP sample into 2 plastic aliquot tubes
Frozen

Fasting Required?
False
Patient Instructions

Reference Range

Normal: No lupus-like anticoagulants (LA) present
LA1: Less than or equal to 45 seconds
LA2: Less than or equal to 38 seconds

Methodology

Clot Detection

Clinical Significance

Lupus-like anticoagulants (LA) are immunoglobulins that interfere with one or more of the in vitro phospholipid-dependent steps of coagulation, resulting in prolonged coagulation tests, especially APTT, dRVVT, and TTI. Circulating lupus-like anticoagulants are recognized as a major cause of both venous and arterial thromboembolic events. Often encountered in settings such as recurrent abortion, deep vein thrombosis, and arterial thrombosis, LA may initially present as a prolonged APTT screen.The antiphospholipid protein antibody family includes lupus-like anticoagulants and cardiolipin antibodies, either of which can cause the syndromes described above. Patients may present with lupus-like anticoagulants and cardiolipin antibodies, or with one or the other. The Circulating Anticoagulant Detection test (#25242) for lupus-like anticoagulants plus Cardiolipin IgG and IgM antibodies (#28102 and #28103) are recommended for patients suspected of having a hypercoagulapathy due to an antiphospholipid protein antibody syndrome.

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