DILUTE RUSSELL VIPER VENOM TIME (DRVVT)
- Code
- 000.0000
- Name
- DILUTE RUSSELL VIPER VENOM TIME (DRVVT)
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- dRVVT
- CPT Codes
- 85613
- Site
- SBMF
- Reference Test
- 25050
Specimen Information
- Type
Blue, Citrate
- Volume
- Transport Info
Separate plasma from cells immediately
• Promptly centrifuge 15 minutes
• Carefully transfer plasma portion of sample to separate plastic tube using plastic pipette
• Centrifuge transferred plasma sample again to produce platelet-poor plasma (PPP)
• Use second plastic pipette to carefully transfer PPP sample into 2 plastic aliquot tubes
Frozen- Fasting Required?
- False
- Patient Instructions
- Reference Range
Normal: No lupus-like anticoagulants (LA) present
LA1: Less than or equal to 45 seconds
LA2: Less than or equal to 38 seconds- Methodology
Clot Detection
Clinical Significance
Lupus-like anticoagulants (LA) are immunoglobulins that interfere with one or more of the in vitro phospholipid-dependent steps of coagulation, resulting in prolonged coagulation tests, especially APTT, dRVVT, and TTI. Circulating lupus-like anticoagulants are recognized as a major cause of both venous and arterial thromboembolic events. Often encountered in settings such as recurrent abortion, deep vein thrombosis, and arterial thrombosis, LA may initially present as a prolonged APTT screen.The antiphospholipid protein antibody family includes lupus-like anticoagulants and cardiolipin antibodies, either of which can cause the syndromes described above. Patients may present with lupus-like anticoagulants and cardiolipin antibodies, or with one or the other. The Circulating Anticoagulant Detection test (#25242) for lupus-like anticoagulants plus Cardiolipin IgG and IgM antibodies (#28102 and #28103) are recommended for patients suspected of having a hypercoagulapathy due to an antiphospholipid protein antibody syndrome.