DIPTHERIA AND TETNUS IgG ANTIBODIES
- DIPTHERIA AND TETNUS IgG ANTIBODIES
- Start Date
- Expiration Date
- CPT Codes
- 86317 x2
- Reference Test
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
Mark specimens clearly as "Pre-Vaccine" or "Post-Vaccine"
- Fasting Required?
- Patient Instructions
- Reference Range
Antibody concentration of > 0.1 IU/mL is usually considered protective for diphtheria or tetanus.
Quantitative Multi-Analyte Fluorescence Detection (MAFD)
Used primarily to determine a patient's response to protein toxoid.
Diphtheria is an acute and contagious disease caused by Corynebacterium diphtheriae . It is characterized by the formation of a fibrinous pseudo-membrane, usually on the respiratory mucosa, and by myocardial and neural tissue damage, secondary to an exotoxin. Because of the severity of the disease and the availability of immunizations, most people in the USA are immunized in early childhood. During an outbreak, known contacts should have their immunization updated. The diphtheria antibody test is used primarily to determine a patient's response to protein toxoid. The majority of this antibody falls within IgG subclass 1. The presence of antibody to diphtheria toxoid ł 0.1 IU is considered protective. Another use of the test is the diagnosis of antibody deficiency in patients with recurrent infections, especially sinopulmonary and gastrointestinal infections. The work-up of patients suspected of antibody deficiency generally includes determination of quantitative concentrations of IgG, IgM, and IgA. If concentrations are low, low normal, or even normal, and antibody deficiency is still strongly suspected, IgG subclass determination and the response to protein antigens such as diphtheria, tetanus toxoid, and influenzae, as well as to pure polysaccharide antigens such as the pneumococcal vaccine, should be determined.