DIPTHERIA AND TETNUS IgG ANTIBODIES

Code
900.1350
Name
DIPTHERIA AND TETNUS IgG ANTIBODIES
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
86317 x2
Site
SBMF
Reference Test
45552
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Mark specimens clearly as "Pre-Vaccine" or "Post-Vaccine"
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Antibody concentration of > 0.1 IU/mL is usually considered protective for diphtheria or tetanus.

Methodology

Quantitative Multi-Analyte Fluorescence Detection (MAFD)

Clinical Significance

Used primarily to determine a patient's response to protein toxoid.

Diphtheria is an acute and contagious disease caused by Corynebacterium diphtheriae . It is characterized by the formation of a fibrinous pseudo-membrane, usually on the respiratory mucosa, and by myocardial and neural tissue damage, secondary to an exotoxin. Because of the severity of the disease and the availability of immunizations, most people in the USA are immunized in early childhood. During an outbreak, known contacts should have their immunization updated. The diphtheria antibody test is used primarily to determine a patient's response to protein toxoid. The majority of this antibody falls within IgG subclass 1. The presence of antibody to diphtheria toxoid ł 0.1 IU is considered protective. Another use of the test is the diagnosis of antibody deficiency in patients with recurrent infections, especially sinopulmonary and gastrointestinal infections. The work-up of patients suspected of antibody deficiency generally includes determination of quantitative concentrations of IgG, IgM, and IgA. If concentrations are low, low normal, or even normal, and antibody deficiency is still strongly suspected, IgG subclass determination and the response to protein antigens such as diphtheria, tetanus toxoid, and influenzae, as well as to pure polysaccharide antigens such as the pneumococcal vaccine, should be determined.

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