DIRECT COOMBS

Code
120.1800
Name
DIRECT COOMBS
Category
None
Department
Blood Bank
Start Date
Expiration Date
Synonyms
DAT
CPT Codes
86880
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Pink,EDTA

Volume

6.0mL

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Negative

Methodology

Antigen-Antibody Reaction

Clinical Significance

It is commonly used in the diagnosis of hemolytic disease of the newborn, autoimmune hemolytic anemia, drug-induced red cell sensitization, and for investigation of transfusion reactions.

The direct antiglobulin (Coombs) test is a one-stage test for the detection of in vivo red cell sensitization. It is commonly used in the diagnosis of hemolytic disease of the newborn, autoimmune hemolytic anemia, drug-induced red cell sensitization, and for investigation of transfusion reactions.In this test, the cells under study are washed thoroughly with saline to remove any unattached serum globulins. The washed cells are then tested with polyspecific antihuman globulin (AHG) serum.Depending on the type of specimen used, a positive reaction indicates the presence of antibodies and/or complement attached to the cell surface.

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