Echovirus Antibodies (Types 6, 7, 9, 11, and 30)
- Code
- 000.0000
- Name
- Echovirus Antibodies (Types 6, 7, 9, 11, and 30)
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- Enterovirus
- CPT Codes
- 86658 x 5
- Site
- SBMF
- Reference Test
- 44167
Specimen Information
- Type
Gold, SST
- Volume
3.0 ml
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated- Fasting Required?
- False
- Patient Instructions
- Reference Range
Echovirus 6: Less than 1:10
Echovirus 7: Less than 1:10
Echovirus 9: Less than 1:10
Echovirus 11: Less than 1:10
Echovirus 30: Less than 1:10Single positive antibody titers of greater than or equal to 1:80 may indicate past or current infection. Seroconversion or an increase in titers between acute and convalescent sera of at least fourfold is considered strong evidence of current or recent infection.
- Methodology
Serum Neutralization Assay
Clinical Significance
Diagnosis of aseptic meningitis, encephalitis, flaccid motor paralysis, exanthems, generalized disease of the newborn, or neonatal diarrhea.
Echoviruses, like the other enteroviruses (Coxsackie A and B, poliovirus), cause a variety of clinical syndromes. These include aseptic meningitis, encephalitis, flaccid motor paralysis, exanthems, generalized disease of the newborn, and neonatal diarrhea. Because of the large number of potential serotypes, serology is of limited use in diagnosis. Viral isolation is the preferred laboratory method. In cases of central nervous system disease, amplification techniques (PCR on CSF) are the most sensitive. Echovirus antibody titers between 1:10 and 1:40 could represent immunity (infection months to years previously) or low titers present early in the course of an infection. Although titers of 1:80 or greater in a single serum specimen strongly suggest current or recent infection, it is preferable to submit acute and convalescent.