Echovirus Antibodies (Types 6, 7, 9, 11, and 30)

Code
000.0000
Name
Echovirus Antibodies (Types 6, 7, 9, 11, and 30)
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Enterovirus
CPT Codes
86658 x 5
Site
SBMF
Reference Test
44167
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

3.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Echovirus 6: Less than 1:10
Echovirus 7: Less than 1:10
Echovirus 9: Less than 1:10
Echovirus 11: Less than 1:10
Echovirus 30: Less than 1:10

Single positive antibody titers of greater than or equal to 1:80 may indicate past or current infection. Seroconversion or an increase in titers between acute and convalescent sera of at least fourfold is considered strong evidence of current or recent infection.

Methodology

Serum Neutralization Assay

Clinical Significance

Diagnosis of aseptic meningitis, encephalitis, flaccid motor paralysis, exanthems, generalized disease of the newborn, or neonatal diarrhea.

Echoviruses, like the other enteroviruses (Coxsackie A and B, poliovirus), cause a variety of clinical syndromes. These include aseptic meningitis, encephalitis, flaccid motor paralysis, exanthems, generalized disease of the newborn, and neonatal diarrhea. Because of the large number of potential serotypes, serology is of limited use in diagnosis. Viral isolation is the preferred laboratory method. In cases of central nervous system disease, amplification techniques (PCR on CSF) are the most sensitive. Echovirus antibody titers between 1:10 and 1:40 could represent immunity (infection months to years previously) or low titers present early in the course of an infection. Although titers of 1:80 or greater in a single serum specimen strongly suggest current or recent infection, it is preferable to submit acute and convalescent.

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