ELECTROPHORESIS, PROTEIN WITH IMMUNOFIXATION, URINE, RANDOM
- Code
- 900.2026
- Name
- ELECTROPHORESIS, PROTEIN WITH IMMUNOFIXATION, URINE, RANDOM
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- CPT Codes
- 82664 84156 86335
- Site
- SBMF
- Reference Test
- 23255
Specimen Information
- Type
Urine Cup
- Volume
20.0 ml
- Transport Info
Refrigerated
- Fasting Required?
- False
- Patient Instructions
- Reference Range
No proteins detected
- Methodology
Zone Electrophoresis
Clinical Significance
Detect a monoclonal light chain in the urine of a patient with (or suspected to have) multiple myeloma, macroglobulinemia, amyloidosis, or related disorders.
Immunofixation electrophoresis (IFE) is the most sensitive method used to detect, confirm, and then characterize the presence of a monoclonal gammopathy identified by serum protein electrophoresis in patients suspected of having a plasma cell dyscrasia (e.g., multiple myeloma, Waldenstrom's macroglobulinemia, monoclonal gammopathy of unknown significance [MGUS], light- or heavy-chain disease) or other lymphoproliferative process. IFE is particularly useful in identifying minor monoclonal proteins, the light chain component of monoclonal proteins, and unknown bands seen on serum protein electrophoresis.A monoclonal protein is found in the serum and/or urine of 99 percent of patients with multiple myeloma. Similar to the normal heavy chain distribution in serum, approximately 50-75 percent of monoclonal gammopathies are IgG, 20 percent are IgA, and less than one percent are IgD.