ELECTROPHORESIS, PROTEIN WITH IMMUNOFIXATION, URINE, RANDOM

Code
900.2026
Name
ELECTROPHORESIS, PROTEIN WITH IMMUNOFIXATION, URINE, RANDOM
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
82664 84156 86335
Site
SBMF
Reference Test
23255
ATLAS Test Code

Specimen Information

Type

Urine Cup

Volume

20.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

No proteins detected

Methodology

Zone Electrophoresis

Clinical Significance

Detect a monoclonal light chain in the urine of a patient with (or suspected to have) multiple myeloma, macroglobulinemia, amyloidosis, or related disorders.

Immunofixation electrophoresis (IFE) is the most sensitive method used to detect, confirm, and then characterize the presence of a monoclonal gammopathy identified by serum protein electrophoresis in patients suspected of having a plasma cell dyscrasia (e.g., multiple myeloma, Waldenstrom's macroglobulinemia, monoclonal gammopathy of unknown significance [MGUS], light- or heavy-chain disease) or other lymphoproliferative process. IFE is particularly useful in identifying minor monoclonal proteins, the light chain component of monoclonal proteins, and unknown bands seen on serum protein electrophoresis.A monoclonal protein is found in the serum and/or urine of 99 percent of patients with multiple myeloma. Similar to the normal heavy chain distribution in serum, approximately 50-75 percent of monoclonal gammopathies are IgG, 20 percent are IgA, and less than one percent are IgD.

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