ALT/SGPT

Code
400.3900
Name
ALT/SGPT
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
ALT; SGPT; Transaminase
CPT Codes
84460
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

Transport Info

Room Temperature
3 day stability

Refrigerated
7 day stability

Fasting Required?
False
Patient Instructions

Reference Range

Male: 13-63 IU/L
Female: 13-54 IU/L

Methodology

Kinetic Rate

Clinical Significance

ALT levels are elevated whenever disease processes affect liver cell integrity

An initial step in detecting liver damage is to determine the presence of certain liver enzymes in the blood. Under normal circumstances, these enzymes reside within the cells of the liver. However, when the liver is injured, these enzymes, including aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT), spill into the blood stream, signifying liver damage. AST (SGOT) is found in a variety of organs, including the liver, heart, muscle, kidney, and brain. It is released into serum when any one of these tissues is damaged. For example, its serum level rises with heart attacks and with muscle disorders. It is, therefore, not a highly specific indicator of liver injury. ALT (SGPT) is, by contrast, normally concentrated in the liver. Since ALT is released into the bloodstream as the result of liver injury, it serves as a more specific indicator of hepatic status.

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