EPITHELIAL SKIN ANTIBODY

Code
000.0000
Name
EPITHELIAL SKIN ANTIBODY
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
88347x4
Site
SBMF
Reference Test
44520
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

2.0 ml

Transport Info

Centrifuge and immediately separate serum into a plastic tube
Room temperature

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Indirect Immunofluorescence

Clinical Significance

Basement membrane zone antibodies by Indirect Immunofluorescence (IIF) of serum
The IIF test is performed on serum to detect the presence and amount of circulating IgG and/or IgA antibodies to epidermal/epithelial antigens. Semiquantitative levels of antibodies are reported as titers. Basement membrane zone antibodies are helpful in diagnosing and distinguishing subepidermal immunobullous diseases such as pemphigoid, epidermolysis bullosa acquisita and linear IgA bullous disease.

Cell surface (also known as intercellular substance and pemphigus) antibodies by Indirect Immunofluorescence (IIF) of serum
The IIF test is performed on serum to detect the presence and amount of circulating IgG and/or IgA antibodies to epidermal/epithelial antigens. Semiquantitative levels of antibodies are reported as titers. Cell surface antibodies are helpful in diagnosing pemphigus, including pemphigus vulgaris, pemphigus foliaceus, pemphigus vegetans and pemphigus erythematosus for IgG cell surface antibodies and IgA pemphigus for IgA cell surface antibodies. Levels of antibodies correlate with disease activity in pemphigus.

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