ESTRADIOL

Code
600.4575
Name
ESTRADIOL
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
E2 Unconjugated
CPT Codes
82670
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
2 days stability

Frozen (Freeze Only once)
6 month stability

Fasting Required?
False
Patient Instructions

No isotopes should be administered 24 hours prior to sample collection.

Reference Range

See Report

Methodology

Chemiluminescence

Clinical Significance

Assess hypothalamic and pituitary function; assess ovarian failure and follicular maturation • Amenorrhea work-up: low result, if gonadotropins high, may indicated ovarian failure; if gonadotropins and estradiol low, consider hypothalamic or pituitary disorder. In males, E2 measurements may be helpful in the assessment of unexplained gynecomastia • In females, E2 measurements are frequently utilized to document hypoestrogenism in cases of cases of delayed puberty, primary and secondary amenorrhea, and menopause • Gonadotropin measurements must be utilized to localize the cause of hypoestrogenism to the ovaries or to a hypothalamic-pituitary source • E2 concentrations greater than 1000 pg/mL are usually observed only during pregnancy or in rare cases of estrogen secreting tumors.

Estrogens are responsible for the development of the secondary female sex characteristics. Together with gestagens, they control all the important female reproductive processes.The biologically most active estrogen is 17b-estradiol. This is a steroid hormone having a molecular weight of 272 daltons. Estrogens are produced primarily in the ovary (follicle, corpus luteum), but small quantities are also formed in the testes and in the adrenal cortex. During pregnancy, estrogens are mainly formed in the placenta. About 98% of estradiol is bound to transport proteins (SHBG = sex hormone binding globulin).Estrogen secretion is biphasic during the menstrual cycle. The determination of estradiol is utilized clinically in the elucidation of fertility disorders in the hypothalamus-pituitary-gonad axis, gynecomastia, estrogen-producing ovarian and testicular tumors and in hyperplasia of the adrenal cortex. Further clinical indications are the monitoring of fertility therapy and determining the time of ovulation within the framework of in vitro fertilization (IVF).

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