ESTROGEN/PROGESTERONE RECEPTOR ASSAY, PARAFFIN BLOCK

Code
000.0000
Name
ESTROGEN/PROGESTERONE RECEPTOR ASSAY, PARAFFIN BLOCK
Category
None
Department
Histology
Start Date
Expiration Date
Synonyms
CPT Codes
88360
Site
SBMF
Reference Test
38551
ATLAS Test Code

Specimen Information

Type

Paraffin block containing embedded tissue

Volume

Transport Info

Room Temperature

Fasting Required?
False
Patient Instructions

Reference Range

Estrogen and progesterone receptors by immunohistochemistry are reported as: positive (with 15% to greater than 90% nuclear positivity), weakly positive (with 5% to 10% nuclear positivity), and negative (with 0% to less than 5%) nuclear positivity.

Methodology

Immunohistochemistry

Clinical Significance

A useful biochemical parameter in deciding which patients with breast cancer should be treated by endocrine therapy such as androgens, tamoxifen, or adrenalectomy.

The hormone receptor assays lend predictive value to the patient's response to endocrine therapy. Evidence exists that the incidence of response is enhanced when progesterone receptor is also present. Meningiomas frequently contain progesterone receptors. Such assays are sometimes useful for female patients with metastatic adenocarcinoma of unknown primary site.

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