Flunitrazepam and Metabolites Screen with Confirmation if Indicated, Urine

Code
000.0000
Name
Flunitrazepam and Metabolites Screen with Confirmation if Indicated, Urine
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Rohypnol, Roofies
CPT Codes
82542
Site
SBMF
Reference Test
46103
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

3.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Negative (less than assay limit of detection)

Methodology

High Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Flunitrazepam (Rohypnol®) is a hypnotic and anesthetic induction agent available in several western European countries. Despite its clinical use throughout the world, Flunitrazepam has never been approved by the Food and Drug Administration for use in the United States. Recently, Flunitrazepam has become a problem in the United States due to illicit trafficking and an increase in recreational use. Most notably, the misuse of Flunitrazepam has been implicated with date rape in a number of U.S. cities. The detection of Flunitrazepam in urine is rare given its rapid and extensive biotransformation to the major urinary metabolite 7-aminoflunitrazepam and at least 10 other metabolites. To effectively detect the presence of this drug, this procedure specifically targets the Flunitrazepam metabolite, 7-aminoflunitrazepam.

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