FLUOXETINE & METABOLITE

Code
000.0000
Name
FLUOXETINE & METABOLITE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Fluoxetine/Norfluoxetine, Oxactin, Prozac, Rapiflux, Sarafem, Selfemra
CPT Codes
80299x2
Site
SBMF
Reference Test
44092
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0 ml

Transport Info

Centrifuged and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

See report

Methodology

Quantitative High Performance Liquid Chromatography (HPLC)

Clinical Significance

Determine levels of fluoxetine and its metabolite, norfluoxetine.

The efficacy of fluoxetine in the treatment of nondelusional, moderately depressed patients is comparable to that of the tricyclic agents; its efficacy in severely depressed hospitalized patients has not been established. In limited studies, fluoxetine was useful in treating patients with atypical depression, panic disorder, and the depressed component of bipolar disorder. Fluoxetine may be indicated as initial therapy in patients with concurrent obsessive-compulsive disorder. Its efficacy in obesity and bulimia is being explored. The selection of fluoxetine appears to be most appropriate for patients who are at special risk from sedative, hypotensive, and anticholinergic side effects caused by other antidepressants. In addition, it appears to be relatively safe for use in the elderly, although its very long elimination half-life may pose special problems for these individuals.

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