FLUOXETINE & METABOLITE
- FLUOXETINE & METABOLITE
- Start Date
- Expiration Date
- Fluoxetine/Norfluoxetine, Oxactin, Prozac, Rapiflux, Sarafem, Selfemra
- CPT Codes
- Reference Test
- Transport Info
Centrifuged and immediately transfer serum to separate plastic tube
- Fasting Required?
- Patient Instructions
- Reference Range
Quantitative High Performance Liquid Chromatography (HPLC)
Determine levels of fluoxetine and its metabolite, norfluoxetine.
The efficacy of fluoxetine in the treatment of nondelusional, moderately depressed patients is comparable to that of the tricyclic agents; its efficacy in severely depressed hospitalized patients has not been established. In limited studies, fluoxetine was useful in treating patients with atypical depression, panic disorder, and the depressed component of bipolar disorder. Fluoxetine may be indicated as initial therapy in patients with concurrent obsessive-compulsive disorder. Its efficacy in obesity and bulimia is being explored. The selection of fluoxetine appears to be most appropriate for patients who are at special risk from sedative, hypotensive, and anticholinergic side effects caused by other antidepressants. In addition, it appears to be relatively safe for use in the elderly, although its very long elimination half-life may pose special problems for these individuals.