FOLATE

Code
600.6225
Name
FOLATE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
FOL
CPT Codes
82746
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Room Temp
2 hrs stability

Refrigerated
2 days stability

Frozen (Freeze Only once)
1 month stability

Protect from light

Fasting Required?
False
Patient Instructions

Protect from light

Reference Range

5.9->24.8 ng/mL

Methodology

Chemiluminescence

Clinical Significance

Diagnose the etiology of anemia.

Nutritional and macrocytic anemias can be caused by a deficiency of folate. This deficiency can result from diets devoid of raw fruits and vegetables, alcoholism, structural/functional damage to digestive or absorptive processes, or pregnancy. In addition, low serum folate during pregnancy has been associated with neural tube defects in the fetus. Dietary deficiency and malabsorption are the major causes of folate deficiency in humans. Folate is necessary for normal metabolism, DNA synthesis and red blood cell regeneration. Untreated deficiencies will lead to megaloblastic anemia. Since a deficiency of either vitamin B12 or folate can cause megaloblastic anemia, it is advisable to determine the concentration of both vitamin B12 and folate in order to properly diagnose the etiology of anemia.

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