FOLLICLE STIMULATING HORMONE

Code
600.4545
Name
FOLLICLE STIMULATING HORMONE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
FSH
CPT Codes
83001
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
2 days stability

Frozen (Freeze Only once)
6 month stability

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Chemiluminescence

Clinical Significance

Excessive FSH in hypogonadism indicates gonadal insufficiency. Pituitary function test, useful to distinguish primary gonadal failure from secondary (hypothalamic/pituitary) causes of menstrual disturbances and amenorrhea. Inadequate corpora lutea are related to low FSH levels. Useful in defining menstrual cycle phases in infertility evaluation of women and testicular dysfunction in men.

FSH (follicle stimulating hormone), like LH (luteinizing hormone), belongs to the gonadotropin family, FSH and LH synergistically regulate and stimulate the growth and function of the gonads (ovaries and testes). Similarly to LH, TSH and hCG, FSH is a glycoprotein consisting of two subunits (a- and b-chains). Its molecular weight is approximately 32,000 D. In women, the gonadotropins act within the hypothalamus-pituitary-ovary regulating circuit to control the menstrual cycle.FSH and LH are released in pulses from the gonadotropic cells of the anterior pituitary. Steroid hormones via negative feedback to the hypothalamus control the levels of the circulating hormones. In the ovaries FSH, together with LH, stimulates the growth and maturation of the follicle and hence also the biosynthesis of estrogens in the follicles. The FSH level shows a peak at mid-cycle, although this is less marked than with LH. Due to changes in ovarian function and reduced estrogen secretion, high FSH concentrations occur during menopause.In men, FSH serves to induce spermatogonium development. The determination of FSH is utilized in the elucidation of functional disorders within the hypothalamus-pituitary-gonad system. The determination of FSH together with LH is indicated for the following: congenital diseases with chromosome aberrations, amenorrhea (causes), polycystic ovaries (PCO) and menopausal syndrome. Depressed gonadotropin levels in men occur in azoospermia.

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