FRUCTOSAMINE, SERUM

Code
000.0000
Name
FRUCTOSAMINE, SERUM
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
82985
Site
SBMF
Reference Test
23480
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Patients should abstain from ascorbic acid (Vitamin C) supplements for a minimum of 24 hours prior to sample collection

Reference Range

Non-diabetic: 186-285 umol/L

Methodology

Spectrophotometry

Clinical Significance

Used as a short- to medium-term indicator of diabetes control.

The measurement of glycated hemoglobin (GHb) has been accepted as a method for assessing long-term diabetic control. The average life span of an RBC is about 120 days, so glycated hemoglobin may not reflect more recent changes in control in a diabetic. Because the turnover rate of proteins is much faster than that of hemoglobins, the measurement of glycated serum proteins (i.e., fructosamines) provides a shorter term, more rapidly responding assessment of diabetic control. The fructosamine measurement reflects an average blood glucose level of the past 2-3 weeks, while GHb values indicate control over a 2-3 month period. Fructosamine levels are directly proportional to serum protein levels (albumin, immunoglobulins). Since the fructosamine level is not given as a percentage of actual serum total protein, a low level may indicate good control or it may indicate low total protein. Not all proteins are glycated at the same rate. Although normal serum protein is largely albumin, in patients with abnormally elevated levels of proteins other than albumin, glycation rates may shift affecting fructosamine levels as well. Since many diabetics can maintain average glucose levels in the normal range, there is no clear distinction between a "normal" and "diabetic" specimen. The higher the fructosamine value, the poorer the degree of glycemic control. Because of this overlap between normal and diabetic ranges, the assay by itself cannot serve as an indicator of diabetes. Relative changes in fructosamine values for a specific individual may have more diagnostic significance than the absolute value. Variations in levels of serum proteins (albumin, IgA, and other immunoglobulins) may affect fructosamine results.

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