GLIADIN ABS IGG, IGA
- Code
- 900.0975
- Name
- GLIADIN ABS IGG, IGA
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- CPT Codes
- 83516 X2
- Site
- SBMF
- Reference Test
- 28193
Specimen Information
- Type
Gold, SST
- Volume
1.0 ml
- Transport Info
Refrigerated
- Fasting Required?
- False
- Patient Instructions
- Reference Range
0.0-7.0 U/mL
< 7.0
7.0 - 10.0
> 10.0 U/mL = Negative
U/mL = Equivocal
U/mL = Positive
Testing is being performed on the Phadia Immunocap 250- Methodology
Enzyme-Linked Immunosorbent Assay (ELISA)
Clinical Significance
The gliadin antibodies (GA) are IgG and IgA antibodies against a group of proteins found in the gluten of wheat and rye grains. The ELISA test for GA is a reliable screening tool for the evaluation of asymptomatic celiac disease in pre- pubertal children with short stature. Celiac disease results from an intolerance to dietary gluten, resulting in small intestinal villous atrophy with subsequent malabsorption and malnutrition. Classic symptoms include: diarrhea, weight loss, abdominal pain and distention, fatigue, oral ulceration, bleeding tendency, proximal myopathy, and bone and joint pain. Short stature, delayed puberty, arthritis, or arthralgia may also result from the untreated disease. GA are useful in screening populations at risk for celiac disease and other gluten- sensitive enteropathies such as dermatitis herpetiformis, and in monitoring patient compliance to a gluten-free diet. In celiac disease, IgG antibodies are more sensitive than IgA antibodies, but IgA antibodies are more specific than IgG antibodies. The level of IgA antibodies decreases with a gluten-free diet. IgA and IgG antibodies rise significantly during gluten challenge, sometimes several months before clinical relapse.