GLIADIN ABS IGG, IGA

Code
900.0975
Name
GLIADIN ABS IGG, IGA
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
83516 X2
Site
SBMF
Reference Test
28193
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

0.0-7.0 U/mL
< 7.0
7.0 - 10.0
> 10.0 U/mL = Negative
U/mL = Equivocal
U/mL = Positive
Testing is being performed on the Phadia Immunocap 250

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

The gliadin antibodies (GA) are IgG and IgA antibodies against a group of proteins found in the gluten of wheat and rye grains. The ELISA test for GA is a reliable screening tool for the evaluation of asymptomatic celiac disease in pre- pubertal children with short stature. Celiac disease results from an intolerance to dietary gluten, resulting in small intestinal villous atrophy with subsequent malabsorption and malnutrition. Classic symptoms include: diarrhea, weight loss, abdominal pain and distention, fatigue, oral ulceration, bleeding tendency, proximal myopathy, and bone and joint pain. Short stature, delayed puberty, arthritis, or arthralgia may also result from the untreated disease. GA are useful in screening populations at risk for celiac disease and other gluten- sensitive enteropathies such as dermatitis herpetiformis, and in monitoring patient compliance to a gluten-free diet. In celiac disease, IgG antibodies are more sensitive than IgA antibodies, but IgA antibodies are more specific than IgG antibodies. The level of IgA antibodies decreases with a gluten-free diet. IgA and IgG antibodies rise significantly during gluten challenge, sometimes several months before clinical relapse.

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