Glomerular Basement Membrane IgG Antibody, MAFD

Code
900.1705
Name
Glomerular Basement Membrane IgG Antibody, MAFD
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Anti-GBM IgG Antibody, GBM IgG Antibody
CPT Codes
83516
Site
SBMF
Reference Test
44225
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater

Methodology

Multi-Analyte Fluorescent Detection (MAFD)

Clinical Significance

The presence of anti-glomerular basement membrane (GBM) antibodies by multi-analyte fluorescent detection (MAFD) may aid in the diagnosis of Goodpasutre syndrome. False positive results may occur due to reactivity against other chains of type IV collagen. If MAFD is negative but there is strong suspicion for disease, renal biopsy may be indicated. A renal biopsy may also be essential in suspected Goodpasture disease with renal involovement, allowing diagnostic confirmation and assesssment of renal prognosis.

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