Ganglioside (GM1) IgG and IgM Antibodies

Code
900.1718
Name
Ganglioside (GM1) IgG and IgM Antibodies
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
GM1, Ganglioside-Monosialic Acid Ab
CPT Codes
83516x2
Site
SBMF
Reference Test
44188
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

GM1 IgG Antibody
29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive

GM1 IgM Antibody
29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

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