Ganglioside (GM1) IgG and IgM Antibodies
- Code
- 900.1718
- Name
- Ganglioside (GM1) IgG and IgM Antibodies
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- GM1, Ganglioside-Monosialic Acid Ab
- CPT Codes
- 83516x2
- Site
- SBMF
- Reference Test
- 44188
Specimen Information
- Type
Gold, SST
- Volume
1.0 ml
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated- Fasting Required?
- False
- Patient Instructions
- Reference Range
GM1 IgG Antibody
29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong PositiveGM1 IgM Antibody
29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive- Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Clinical Significance
Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.