HALOPERIDOL

Code
900.1719
Name
HALOPERIDOL
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Haldol
CPT Codes
80173
Site
SBMF
Reference Test
44082
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Therapeutic range: 2.0-15.0 ng/mL

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Haloperidol is an antipsychotic tranquilizer used to control acute and chronic psychotic disorders, for the control of Tourette syndrome, and for the treatment of severe behavior problems in hyperactive children. Haloperidol is metabolized by dealkalization, oxidation, and conjugation; the hydroxy derivative is active but concentrations are very low. Haloperidol should be monitored to assess and optimize dosing regimens and maintenance therapy since the relationship between dosage and serum levels at steady-state can be highly variable. The drug should also be monitored to assess adverse reactions and changes associated with coadministered drugs. Haloperidol can increase serum tricyclic level, increase the toxicity of lithium, inhibit hypertensive action and antagonize the stimulant effect of amphetamines. The half-life of Haloperidol is 15-40 hours.

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