HALOPERIDOL
- Code
- 900.1719
- Name
- HALOPERIDOL
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- Haldol
- CPT Codes
- 80173
- Site
- SBMF
- Reference Test
- 44082
Specimen Information
- Type
Red, Plain
- Volume
1.0 ml
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated- Fasting Required?
- False
- Patient Instructions
- Reference Range
Therapeutic range: 2.0-15.0 ng/mL
- Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Clinical Significance
Haloperidol is an antipsychotic tranquilizer used to control acute and chronic psychotic disorders, for the control of Tourette syndrome, and for the treatment of severe behavior problems in hyperactive children. Haloperidol is metabolized by dealkalization, oxidation, and conjugation; the hydroxy derivative is active but concentrations are very low. Haloperidol should be monitored to assess and optimize dosing regimens and maintenance therapy since the relationship between dosage and serum levels at steady-state can be highly variable. The drug should also be monitored to assess adverse reactions and changes associated with coadministered drugs. Haloperidol can increase serum tricyclic level, increase the toxicity of lithium, inhibit hypertensive action and antagonize the stimulant effect of amphetamines. The half-life of Haloperidol is 15-40 hours.