HANTAVIRUS IGG/IGM ANTIBODIES BY ELISA

Code
000.0000
Name
HANTAVIRUS IGG/IGM ANTIBODIES BY ELISA
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
86790 x 2
Site
SBMF
Reference Test
44389
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

<=1.10

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus, which causes hantavirus pulmonary syndrome, a severe and possibly fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala viruses) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States.

Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All screen IgM positive samples are then tested for SNV-specific IgM at an additional charge; further, any screen IgM positive samples that are also screen IgG positive are tested for SNV-specific IgG at an additional charge.

A positive result in the screening ELISA but a negative result in the confirmatory assays may indicate reactivity to a hantavirus causing hemorrhagic fever with renal syndrome.

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