HANTAVIRUS IGG/IGM ANTIBODIES BY ELISA
- HANTAVIRUS IGG/IGM ANTIBODIES BY ELISA
- Start Date
- Expiration Date
- CPT Codes
- 86790 x 2
- Reference Test
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
- Fasting Required?
- Patient Instructions
- Reference Range
Enzyme-Linked Immunosorbent Assay (ELISA)
Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus, which causes hantavirus pulmonary syndrome, a severe and possibly fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala viruses) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States.
Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All screen IgM positive samples are then tested for SNV-specific IgM at an additional charge; further, any screen IgM positive samples that are also screen IgG positive are tested for SNV-specific IgG at an additional charge.
A positive result in the screening ELISA but a negative result in the confirmatory assays may indicate reactivity to a hantavirus causing hemorrhagic fever with renal syndrome.