AMIODARONE (CORDARONE) LEVEL

Code
900.0300
Name
AMIODARONE (CORDARONE) LEVEL
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
N-Desethylamiodarone; Desethylamiodarone; Cordarone
CPT Codes
80299
Site
SBMF
Reference Test
23008
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Amiodarone Therapeutic Range: 1.0-2.5 µg/mL
N-desethylamiodarone Therapeutic Range: 1.0-2.5 µg/mL

Critical High Value:
Amiodarone Toxic Level: > 3.5 µg/mL
N-desethylamiodarone Toxic Level: > 3.5 µg/mL

Methodology

High Performance Liquid Chromatography (HPLC)

Clinical Significance

Monitor therapy. Assess compliance and possible toxicity.

Amiodarone is considered a Class III antiarrhythmic drug used for treatment of life-threatening recurrent ventricular arrhythmias that have not responded to adequate doses of other available antiarrhythmics. Due to its significant side effects, amiodarone is reserved as a last resort treatment for cardiac arrhythmia. N-desethylamiodarone is the major active metabolite of amiodarone and it is not observed until a few days after continuous infusion. At equilibrium, both amiodarone and N-desethylamiodarone are approximately equal in the pharmacokinetic properties and blood concentrations. Amiodarone is eliminated primarily by hepatic metabolism and biliary excretion and there is minimal excretion of amiodarone and metabolite in the urine. The early elimination phases with a half-life of 2-3 days and followed by a slower elimination of a mean half-life of 53 days. Due to its prolonged elimination, dosage adjustments are based on the degree of pulmonary and thyroid toxicity noted.

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